![]() Patients were imaged by PET/CT (N = 17) or PET (N = 17) in accordance with standard protocol. Written consent was received and the project was approved by the local Institutional Review Board (Genetic Alterations in Human Lung Cancer IRBMED #1993–0215 (HUM00037727)). ![]() Thirty-four patients who had documented PET scans and resected non-small cell lung cancer between 19, for whom relevant tissue samples were available, were identified. ![]() Lung cancer tissues were collected from patients undergoing curative lung cancer surgery as part of a prospectively collected tissue bank beginning in 1991 through the present at the University of Michigan Health System. This study–which to our knowledge is the largest PET radiogenomic analysis to date–aims to better characterize the genomic alterations associated with increased FDG uptake in early stage lung cancers. ĭespite this, the genetic abnormalities associated with increased PET intensity remain marginally understood. showed an association between PET intensity and NF-κB expression. A similar study in lung cancer by Nair et al. Indeed, a direct clinical correlation between MYC amplification and PET intensity has been demonstrated in human breast cancer. MYC–which interacts with HIF1 –has been shown to regulate many glycolytic enzymes, including GLUT transporters, lactate dehydrogenase (LDH), and PDK1. HIF1 has been shown to activate pyruvate dehydrogenase kinases (PDKs), inhibiting the entry of pyruvate into the mitochondria for oxidative phosphorylation. Many signaling pathways have been implicated in altering cancer cell metabolism, perhaps the most common being the phosphoinositide-3-kinase (PI3K) and HIF1 pathways. PET imaging provides a unique insight into tumor cell metabolism. the intensity) predicts survival, even among early stage surgical candidates. It has been well-established that the degree of FDG uptake by NSCLC tumors (i.e. FDG is a fluorescent glucose analog that accumulates at sites with elevated glucose metabolism, including many tumors. 18F-2-deoxy-D-glucose (FDG) positron emission tomography (PET scan) has become a standard tool for determining the operative candidacy of individuals with lung cancer by evaluating for the presence of regional or systemic metastases. The most common histology of lung cancer is non-small-cell lung cancer (NSCLC) which accounts for approximately 85% of cases of NSCLC, the most common pathologies are adenocarcinoma (40%), squamous cell carcinoma (30%), and large-cell carcinoma (10%). Even when diagnosed at an early stage, patients still have high rates of recurrence. Lung cancer continues to be the number one cause of cancer-related deaths in the developed world. Reddy, Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing 1, * Beer, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – review & editing, 1 and Rishindra M. Lynch, Data curation, Supervision, Writing – review & editing, 1 Lili Zhao, Formal analysis, Methodology, Validation, 3 David G. Carrott, Data curation, Supervision, Writing – review & editing, 1 William R. Chang, Data curation, Supervision, Writing – review & editing, 1 Philip W. Orringer, Data curation, Investigation, Supervision, Writing – review & editing, 1 Jules Lin, Data curation, Supervision, Writing – review & editing, 1 Andrew C. Brown, Conceptualization, Data curation, 2 Mark B. Heiden, Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Visualization, Writing – original draft, Writing – review & editing, 1 Guoan Chen, Formal analysis, 1 Matthew Hermann, Data curation, 2 Richard K.
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